Automated description from the Alliance of Genome Resources
A structural constituent of cytoskeleton. Involved in several processes, including intermediate filament cytoskeleton organization; keratinocyte migration; and skin development. Localizes to the intermediate filament. Used to study nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Human ortholog(s) of this gene implicated in ectodermal dysplasia and pachyonychia congenita. Is expressed in alimentary system; lower urinary tract; respiratory system; sensory organ; and skin. Orthologous to human KRT16 (keratin 16).