Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Krt16. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Krt16
  • participates in the following biological processes:
    • intermediate filament cytoskeleton organization ^[1]
  • performs the following molecular functions:
    • structural constituent of cytoskeleton ^[1]
  • is located in the following cellular components:
    • intermediate filament ^[1]
• The gene product of Krt16 has been shown to bind to the gene products of Tradd. ^[2]

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Summary text based on GO annotations supported by structural data

• Krt16 encodes a protein or proteins that contain the following InterPro domains: Filament, Intermediate filament protein, Intermediate filament protein, conserved site, Keratin, type I, indicating that the gene product:
  • performs the following molecular functions:
    • structural molecule activity

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References

1. Bernot KM et al. (2002) Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle. J Invest Dermatol, 119:1137-49. (PubMed:12445204)
2. Tong X et al. (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev, 20:1353-64. (PubMed:16702408)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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