Automated description from the Alliance of Genome Resources (Release 7.0.0)
A structural constituent of cytoskeleton. Involved in several processes, including establishment of skin barrier; keratinization; and keratinocyte migration. Acts upstream of or within intermediate filament cytoskeleton organization. Located in intermediate filament. Is active in cornified envelope. Is expressed in several structures, including alimentary system; lower urinary tract; respiratory system; sensory organ; and skin. Used to study nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Human ortholog(s) of this gene implicated in ectodermal dysplasia; focal nonepidermolytic palmoplantar keratoderma 1; and pachyonychia congenita. Orthologous to human KRT16 (keratin 16).