Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Krt10. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Krt10
  • participates in the following biological processes:
    • cellular response to calcium ion ^[2]
    • epithelial cell differentiation ^[2]
  • is located in the following cellular components:
    • keratin filament ^{[1, 3]}
• The gene product of Krt10 has been shown to bind to the gene products of Chuk. ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Krt10:
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Krt10 encodes a protein or proteins that contain the following InterPro domains: Filament, Intermediate filament protein, Intermediate filament protein, conserved site, Keratin, type I, indicating that the gene product:
  • performs the following molecular functions:
    • structural molecule activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Krt10 indicates that it:
  • is located in the following cellular components:
    • intermediate filament

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References

1. Cheng X et al. (2004) Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol Cell Biol, 24:154-63. (PubMed:14673151)
2. Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell, 136:1122-35. (PubMed:19303854)
3. Kartasova T et al. (1993) Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network. J Cell Biol, 120:1251-61. (PubMed:7679677)
4. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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