Automated description from the Alliance of Genome Resources
Exhibits GTPase activity. Involved in several processes, including endocrine signaling; forebrain astrocyte development; and modulation of chemical synaptic transmission. Localizes to the membrane. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; autoimmune lymphoproliferative syndrome type 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Orthologous to human KRAS (KRAS proto-oncogene, GTPase).