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Gene Ontology Classifications
Symbol
Name
ID
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
MGI:96680

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kras. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Allen NP et al. (2007) RASSF6 is a novel member of the RASSF family of tumor suppressors. Oncogene, 26:6203-11. (PubMed:17404571)
  2. Ardito CM et al. (2012) EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell, 22:304-17. (PubMed:22975374)
  3. Bergo MO et al. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest, 113:539-50. (PubMed:14966563)
  4. Chang DR et al. (2013) Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A, 110:18042-51. (PubMed:24058167)
  5. Costa RM et al. (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415:526-30. (PubMed:11793011)
  6. Dasgupta B et al. (2005) Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. Cancer Res, 65:236-45. (PubMed:15665300)
  7. Kim E et al. (1999) Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem, 274:8383-90. (PubMed:10085069)
  8. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  9. Takahashi C et al. (2004) Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression. Mol Cell Biol, 24:10406-15. (PubMed:15542848)
  10. Vogel KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci, 15:398-407. (PubMed:10845775)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory