Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits SH2 domain binding activity; protease binding activity; and stem cell factor receptor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; hemopoiesis; and positive regulation of macromolecule metabolic process. Localizes to cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Used to study gastrointestinal stromal tumor; macrocytic anemia; mastocytosis; and piebaldism. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
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