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Gene Ontology Classifications
Symbol
Name
ID
Jup
junction plakoglobin
MGI:96650

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Jup. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 26, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Acehan D et al. (2008) Plakoglobin is required for effective intermediate filament anchorage to desmosomes. J Invest Dermatol, 128:2665-75. (PubMed:18496566)
  2. Besco JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res, 1116:50-7. (PubMed:16973135)
  3. Bierkamp C et al. (1996) Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol, 180:780-5. (PubMed:8954745)
  4. Bierkamp C et al. (1999) Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development, 126:371-81. (PubMed:9847250)
  5. Butz S et al. (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes Commun, 3:337-52. (PubMed:8821035)
  6. Cheng X et al. (2004) Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol Cell Biol, 24:154-63. (PubMed:14673151)
  7. Gallicano GI et al. (1998) Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol, 143:2009-22. (PubMed:9864371)
  8. Gual P et al. (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia, 46:1532-42. (PubMed:14579029)
  9. Haegel H et al. (1995) Lack of beta-catenin affects mouse development at gastrulation. Development, 121:3529-37. (PubMed:8582267)
  10. Hatsell S et al. (2003) Plakoglobin is O-glycosylated close to the N-terminal destruction box. J Biol Chem, 278:37745-52. (PubMed:12847106)
  11. Huelsken J et al. (2000) Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol, 148:567-78. (PubMed:10662781)
  12. Thomas NM et al. (2011) Sex differences in expression and subcellular localization of heart rhythm determinant proteins. Biochem Biophys Res Commun, 406:117-22. (PubMed:21296051)
  13. Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J, 24:1146-56. (PubMed:15775979)
  14. Walker JL et al. (2008) Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn, 237:3128-41. (PubMed:18816447)
  15. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
  16. Yang Z et al. (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res, 99:646-55. (PubMed:16917092)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory