Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in calcium ion transport into cytosol. Acts upstream of or within several processes, including long-term synaptic potentiation; memory; and sensory perception of taste. Located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Is expressed in several structures, including jaw; liver; sensory organ; skeleton; and spleen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).