Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in several processes, including calcium ion transport into cytosol; long-term synaptic potentiation; and sensory perception of taste. Localizes to cytoplasm; endoplasmic reticulum membrane; and nuclear lumen. Is expressed in several structures, including jaw; liver; sensory organ; skeleton; and spleen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).