Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels and phosphatidylinositol binding activity. Involved in several processes, including cellular calcium ion homeostasis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and voluntary musculoskeletal movement. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; calcineurin complex; and nucleus. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1).