Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itgb6. (This text reflects annotations as of Tuesday, May 21, 2013.)

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on physical interactions, that the gene product of Itgb6
  • performs the following molecular functions:
    • integrin binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Itgb6
  • participates in the following biological processes:
    • inflammatory response ^[1]

---

Summary text based on GO annotations supported by structural data

• Itgb6 encodes a protein or proteins that contain the following InterPro domains: Integrin beta subunit, Integrin beta subunit, cytoplasmic domain, Integrin beta subunit, N-terminal, Integrin beta subunit, tail, Integrin beta-6 subunit, Plexin-like fold, Plexin/semaphorin/integrin, von Willebrand factor, type A, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
    • cell-matrix adhesion
    • integrin-mediated signaling pathway
    • multicellular organismal development
  • performs the following molecular functions:
    • receptor activity
  • is located in the following cellular components:
    • integrin complex
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Itgb6 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • integrin-mediated signaling pathway
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Ludlow A et al. (2005) Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med, 9:421-37. (PubMed:15963261)
2. Wada J et al. (1996) Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. J Cell Biol, 132:1161-76. (PubMed:8601592)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---