Automated description from the Alliance of Genome Resources
Exhibits amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including activated T cell proliferation; endocytosis; and leukocyte migration. Localizes to the cell surface; integrin alphaM-beta2 complex; and membrane raft. Predicted to colocalize with the cytoplasmic region. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Orthologous to human ITGB2 (integrin subunit beta 2).