Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itgax. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Itgax
  • participates in the following biological processes:
    • defense response to virus ^[4]
  • is located in the following cellular components:
    • external side of plasma membrane ^{[1, 2, 3, 4, 5, 6, 7, 8, 9]}

---

Summary text based on GO annotations supported by structural data

• Itgax encodes a protein or proteins that contain the following InterPro domains: FG-GAP repeat, Integrin alpha beta-propellor, Integrin alpha chain, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, Integrin alpha-2, von Willebrand factor, type A, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • integrin complex

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Itgax indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • integrin-mediated signaling pathway
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Carlyle JR et al. (2004) Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A, 101:3527-32. (PubMed:14990792)
2. Dai YD et al. (2009) Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes, 58:156-64. (PubMed:18984740)
3. Guerriero A et al. (2000) PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood, 95:879-85. (PubMed:10648399)
4. Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol, 178:2361-9. (PubMed:17277142)
5. Liu Y et al. (1992) Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur J Immunol, 22:2855-9. (PubMed:1385153)
6. Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol, 224:98-105. (PubMed:14609575)
7. Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab, 10:229-40. (PubMed:19723499)
8. Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol, 225:21-32. (PubMed:14643301)
9. Yokota A et al. (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol Immunol, 47:285-93. (PubMed:12801066)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---