Automated description from the Alliance of Genome Resources
Exhibits integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Localizes to the external side of plasma membrane; integrin alphav-beta5 complex; and integrin alphav-beta6 complex. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Is expressed in several structures, including alimentary system; embryo mesenchyme; extraembryonic component; skeletal muscle; and ventricular layer. Orthologous to human ITGAV (integrin subunit alpha V).