Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; leukocyte migration; and positive regulation of neuron death. Localizes to external side of plasma membrane; integrin alphaM-beta2 complex; and nucleus. Is expressed in several structures, including central nervous system; heart; renal interstitium; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).