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Gene Ontology Classifications
integrin alpha 6

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itga6. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Baudoin C et al. (1998) Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev, 12:1202-16. (PubMed:9553049)
  2. Cooper HM et al. (1991) The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. J Cell Biol, 115:843-50. (PubMed:1833411)
  3. Davies D et al. (2002) Differential expression of alpha3 and alpha6 integrins in the developing mouse inner ear. J Comp Neurol, 445:122-32. (PubMed:11891657)
  4. Dowling J et al. (1996) Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol, 134:559-72. (PubMed:8707838)
  5. Durbeej M et al. (1998) Distribution of dystroglycan in normal adult mouse tissues. J Histochem Cytochem, 46:449-57. (PubMed:9524190)
  6. Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell, 136:1122-35. (PubMed:19303854)
  7. Fukumoto S et al. (2006) Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J Biol Chem, 281:5008-16. (PubMed:16365040)
  8. Greene SB et al. (2010) A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci, 123:606-18. (PubMed:20103531)
  9. He ZY et al. (2003) None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev Biol, 254:226-37. (PubMed:12591243)
  10. Kadmon G et al. (1995) Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem Biophys Res Commun, 214:94-101. (PubMed:7669058)
  11. Kadoya Y et al. (1993) Distribution of alpha 6 integrin subunit in developing mouse submandibular gland. J Histochem Cytochem, 41:1707-14. (PubMed:8409377)
  12. Leimeister C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev Genet, 24:273-83. (PubMed:10322635)
  13. Moulson CL et al. (2001) Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo. Dev Dyn, 222:101-14. (PubMed:11507772)
  14. Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol, 193:235-50. (PubMed:21464233)
  15. Romano RA et al. (2012) DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development, 139:772-82. (PubMed:22274697)
  16. Rosahl TW et al. (1995) Essential functions of synapsins I and II in synaptic vesicle regulation [see comments] Nature, 375:488-93. (PubMed:7777057)
  17. Ruiz P et al. (1995) Alpha 6 integrins participate in pro-T cell homing to the thymus. Eur J Immunol, 25:2034-41. (PubMed:7621877)
  18. Ruppert M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol, 131:1881-91. (PubMed:8557754)
  19. Sakai T et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev, 17:926-40. (PubMed:12670870)
  20. Sutherland AE et al. (1993) Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development, 119:1175-86. (PubMed:8306881)
  21. Uchio-Yamada K et al. (2001) Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome. J Vet Med Sci, 63:1171-8. (PubMed:11767049)
  22. Wadehra M et al. (2002) The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem, 277:41094-100. (PubMed:12189152)
  23. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
  24. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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