Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itga6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Itga6
  • participates in the following biological processes:
    • brown fat cell differentiation ^[22]
    • cell adhesion mediated by integrin ^[1]
    • cellular response to extracellular stimulus ^[11]
    • positive regulation of cell-cell adhesion ^[9]
  • is located in the following cellular components:
    • basal part of cell ^[20]
    • basal plasma membrane ^{[12, 13]}
    • basement membrane ^[4]
    • basolateral plasma membrane ^[2]
    • cell surface ^{[1, 19]}
    • external side of plasma membrane ^{[5, 7, 17]}
    • hemidesmosome ^[14]
    • integrin complex ^[3]
    • plasma membrane ^{[2, 8, 10, 18, 21]}
• Researchers have inferred, based on physical interactions, that the gene product of Itga6
  • performs the following molecular functions:
    • integrin binding ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Itga6
  • participates in the following biological processes:
    • cell-matrix adhesion ^[6]
    • filopodium assembly ^[6]
    • leukocyte migration ^[16]
    • odontogenesis of dentin-containing tooth ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Itga6
  • participates in the following biological processes:
    • leukocyte migration based on interactions with Syn2 ^[15]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Itga6:
  • participates in the following biological processes:
    • cell-cell adhesion
    • negative regulation of apoptotic process
    • positive regulation of apoptotic process
    • positive regulation of cell-substrate adhesion
    • positive regulation of phosphorylation
    • positive regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • laminin binding
    • protein complex binding
  • is located in the following cellular components:
    • alpha6-beta4 integrin complex
    • cell-cell adherens junction
    • filopodium
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Itga6 encodes a protein or proteins that contain the following InterPro domains: FG-GAP repeat, Integrin alpha beta-propellor, Integrin alpha chain, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, Integrin alpha-2, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Itga6 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • integrin-mediated signaling pathway
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Cooper HM et al. (1991) The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. J Cell Biol, 115:843-50. (PubMed:1833411)
2. Davies D et al. (2002) Differential expression of alpha3 and alpha6 integrins in the developing mouse inner ear. J Comp Neurol, 445:122-32. (PubMed:11891657)
3. Dowling J et al. (1996) Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol, 134:559-72. (PubMed:8707838)
4. Durbeej M et al. (1998) Distribution of dystroglycan in normal adult mouse tissues. J Histochem Cytochem, 46:449-57. (PubMed:9524190)
5. Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell, 136:1122-35. (PubMed:19303854)
6. Fukumoto S et al. (2006) Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J Biol Chem, 281:5008-16. (PubMed:16365040)
7. Greene SB et al. (2010) A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci, 123:606-18. (PubMed:20103531)
8. He ZY et al. (2003) None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev Biol, 254:226-37. (PubMed:12591243)
9. Kadmon G et al. (1995) Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem Biophys Res Commun, 214:94-101. (PubMed:7669058)
10. Kadoya Y et al. (1993) Distribution of alpha 6 integrin subunit in developing mouse submandibular gland. J Histochem Cytochem, 41:1707-14. (PubMed:8409377)
11. Leimeister C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev Genet, 24:273-83. (PubMed:10322635)
12. Moulson CL et al. (2001) Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo. Dev Dyn, 222:101-14. (PubMed:11507772)
13. Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol, 193:235-50. (PubMed:21464233)
14. Romano RA et al. (2012) DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development, 139:772-82. (PubMed:22274697)
15. Rosahl TW et al. (1995) Essential functions of synapsins I and II in synaptic vesicle regulation [see comments] Nature, 375:488-93. (PubMed:7777057)
16. Ruiz P et al. (1995) Alpha 6 integrins participate in pro-T cell homing to the thymus. Eur J Immunol, 25:2034-41. (PubMed:7621877)
17. Ruppert M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol, 131:1881-91. (PubMed:8557754)
18. Sakai T et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev, 17:926-40. (PubMed:12670870)
19. Sutherland AE et al. (1993) Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development, 119:1175-86. (PubMed:8306881)
20. Uchio-Yamada K et al. (2001) Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome. J Vet Med Sci, 63:1171-8. (PubMed:11767049)
21. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
22. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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