Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itga2b. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Itga2b
  • is located in the following cellular components:
    • external side of plasma membrane ^{[1, 2, 4]}
    • focal adhesion ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Itga2b
  • participates in the following biological processes:
    • cell-matrix adhesion ^[3]
  • performs the following molecular functions:
    • extracellular matrix binding ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Itga2b:
  • participates in the following biological processes:
    • platelet aggregation
    • positive regulation of leukocyte migration
  • performs the following molecular functions:
    • fibrinogen binding
    • identical protein binding
  • is located in the following cellular components:
    • cell surface

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Summary text based on GO annotations supported by structural data

• Itga2b encodes a protein or proteins that contain the following InterPro domains: FG-GAP repeat, Integrin alpha beta-propellor, Integrin alpha chain, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, Integrin alpha-2, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • integrin complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Itga2b indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • integrin-mediated signaling pathway
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Ferkowicz MJ et al. (2003) CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development, 130:4393-403. (PubMed:12900455)
2. Levi BP et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood, 113:1670-80. (PubMed:18971422)
3. Rout UK et al. (2004) Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells. Dev Biol, 268:135-51. (PubMed:15031111)
4. Serrano AG et al. (2010) Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood, 115:3895-8. (PubMed:20228271)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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