Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Irf1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Irf1
  • participates in the following biological processes:
    • negative regulation of transcription, DNA-dependent ^[4]
    • positive regulation of interleukin-12 biosynthetic process ^[7]
    • positive regulation of transcription from RNA polymerase II promoter ^[2]
    • positive regulation of transcription, DNA-dependent ^[7]
  • performs the following molecular functions:
    • DNA binding ^[7]
    • sequence-specific DNA binding ^[2]
    • sequence-specific DNA binding transcription factor activity ^{[2, 7]}
  • is located in the following cellular components:
    • cytoplasm ^[8]
    • nucleus ^[8]
• The gene product of Irf1 has been shown to bind to the gene products of Brd4, Cdk9, Myd88. ^{[5, 6, 8, 10]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Irf1
  • participates in the following biological processes:
    • CD8-positive, alpha-beta T cell differentiation ^[9]
    • defense response to virus ^[3]
    • interferon-gamma-mediated signaling pathway ^[1]
    • negative regulation of regulatory T cell differentiation ^[4]
    • positive regulation of interleukin-12 biosynthetic process ^[7]
    • positive regulation of transcription, DNA-dependent ^[11]
    • positive regulation of type I interferon production ^[8]
    • regulation of CD8-positive, alpha-beta T cell proliferation ^[1]
    • regulation of gene expression ^[9]
    • regulation of MyD88-dependent toll-like receptor signaling pathway ^[8]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Irf1
  • is located in the following cellular components:
    • nucleus ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Irf1:
  • participates in the following biological processes:
    • cell cycle arrest
    • cellular response to interferon-beta
    • cellular response to interleukin-1
    • cellular response to peptide hormone stimulus
    • cellular response to tumor necrosis factor
    • defense response to virus
    • I-kappaB kinase/NF-kappaB cascade
    • induction of apoptosis
    • negative regulation of transcription, DNA-dependent
    • negative regulation of tyrosine phosphorylation of Stat1 protein
    • positive regulation of cell death
    • positive regulation of interferon-beta production
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription, DNA-dependent
    • response to growth hormone stimulus
  • performs the following molecular functions:
    • RNA polymerase II core promoter proximal region sequence-specific DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nuclear chromatin
    • nucleus

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Summary text based on GO annotations supported by structural data

• Irf1 encodes a protein or proteins that contain the following InterPro domains: Interferon regulatory factor DNA-binding domain, Interferon regulatory factor, conserved site, Interferon regulatory factor-1/2, Winged helix-turn-helix DNA-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • regulatory region DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Irf1 indicates that it:
  • participates in the following biological processes:
    • innate immune response
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Brien JD et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog, 7:e1002230. (PubMed:21909274)
2. Byun SJ et al. (2007) IFN-gamma upregulates expression of the mouse complement C1rA gene in keratinocytes via IFN-regulatory factor-1. J Invest Dermatol, 127:1187-96. (PubMed:17159910)
3. Dixit E et al. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell, 141:668-81. (PubMed:20451243)
4. Fragale A et al. (2008) IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression. J Immunol, 181:1673-82. (PubMed:18641303)
5. Kojic S et al. (2010) A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys, 502:60-7. (PubMed:20599664)
6. Li S et al. (2011) Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity, 35:426-40. (PubMed:21903422)
7. Liu J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J Exp Med, 198:1265-76. (PubMed:14568984)
8. Negishi H et al. (2006) Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A, 103:15136-41. (PubMed:17018642)
9. Ohteki T et al. (2001) Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol, 166:6509-13. (PubMed:11359801)
10. Okamura D et al. (2012) Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev, 26:2477-82. (PubMed:23154982)
11. Stirnweiss A et al. (2010) IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J Immunol, 184:5179-85. (PubMed:20308629)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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