About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Ins2
insulin II
MGI:96573

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ins2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Chu K et al. (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes, 54:1064-73. (PubMed:15793245)
  2. Font de Mora J et al. (2003) Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J, 22:3039-49. (PubMed:12805218)
  3. Fowler JD et al. (2009) Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab, 296:E1383-91. (PubMed:19293336)
  4. Kitamura T et al. (2002) Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem J, 366:737-44. (PubMed:12059784)
  5. Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest, 110:1839-47. (PubMed:12488434)
  6. Oyadomari S et al. (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest, 109:525-32. (PubMed:11854325)
  7. Rochat A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol Biol Cell, 15:4544-55. (PubMed:15282335)
  8. Salvatore P et al. (1998) Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN. J Biol Chem, 273:6989-97. (PubMed:9507006)
  9. Streeper RS et al. (1998) Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription. Proc Natl Acad Sci U S A, 95:9208-13. (PubMed:9689059)
  10. Tsuji Y et al. (2001) Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice. Diabetes, 50:1455-63. (PubMed:11375348)
  11. Varadi A et al. (2005) Myosin Va transports dense core secretory vesicles in pancreatic MIN6 {beta}-cells. Mol Biol Cell, 16:2670-80. (PubMed:15788565)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory