Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il4
  • participates in the following biological processes:
    • B cell activation ^[7]
    • B cell costimulation ^[10]
    • innate immune response in mucosa ^[26]
    • negative regulation of apoptotic process ^[20]
    • negative regulation of osteoclast differentiation ^[21]
    • negative regulation of T cell activation ^[9]
    • negative regulation of T-helper 17 cell differentiation ^[38]
    • positive regulation of activated T cell proliferation ^{[17, 28]}
    • positive regulation of B cell activation ^[23]
    • positive regulation of B cell proliferation ^{[1, 34]}
    • positive regulation of chemokine biosynthetic process ^[32]
    • positive regulation of isotype switching to IgE isotypes ^[4]
    • positive regulation of isotype switching to IgG isotypes ^{[4, 13]}
    • positive regulation of MHC class II biosynthetic process ^{[37, 39]}
    • positive regulation of peptidyl-tyrosine phosphorylation ^[41]
    • positive regulation of sequence-specific DNA binding transcription factor activity ^[36]
    • positive regulation of T cell proliferation ^{[3, 9]}
    • positive regulation of transcription from RNA polymerase II promoter ^{[3, 9, 24, 31, 33]}
    • positive regulation of transcription, DNA-dependent ^{[8, 36]}
    • positive regulation of tyrosine phosphorylation of Stat5 protein ^[28]
    • regulation of immune response ^[13]
    • regulation of phosphorylation ^[2]
    • T-helper 2 cell differentiation ^[40]
  • performs the following molecular functions:
    • cytokine activity ^{[3, 17, 28, 34, 37, 39]}
  • is located in the following cellular components:
    • external side of plasma membrane ^{[15, 25, 30, 35, 42]}
    • extracellular space ^{[5, 6, 12, 16, 18, 22, 27, 29]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Il4
  • participates in the following biological processes:
    • cholesterol metabolic process ^[19]
    • defense response to protozoan ^[14]
• Researchers have inferred, based on genetic interactions, that the gene product of Il4
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Stat6 ^[11]
    • T-helper 1 cell lineage commitment based on interactions with Stat6 ^[40]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il4:
  • participates in the following biological processes:
    • dendritic cell differentiation
    • negative regulation of acute inflammatory response
    • negative regulation of chronic inflammatory response
    • negative regulation of macrophage activation
    • negative regulation of nitric oxide biosynthetic process
    • negative regulation of transcription, DNA-dependent
    • positive regulation of cell proliferation
    • positive regulation of interleukin-10 production
    • positive regulation of interleukin-13 production
    • positive regulation of T cell differentiation
    • positive regulation of transcription, DNA-dependent
    • regulation of inflammatory response
    • regulation of proton transport
    • T-helper 2 cell cytokine production
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Il4 encodes a protein or proteins that contain the following InterPro domains: Four-helical cytokine, core, Four-helical cytokine-like, core, Interleukin-4, Interleukin-4/interleukin-13, Interleukin-4/interleukin-13, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • performs the following molecular functions:
    • cytokine receptor binding
    • growth factor activity
    • interleukin-4 receptor binding
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il4 indicates that it:
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • extracellular region

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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