About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Il3
interleukin 3
MGI:96552

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il3. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Antoku K et al. (2001) Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem Biophys Res Commun, 286:1003-10. (PubMed:11527400)
  2. Barge RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett, 409:207-10. (PubMed:9202146)
  3. Chiang CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol, 23:6350-62. (PubMed:12944463)
  4. Hilton DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J, 13:4765-75. (PubMed:7957045)
  5. Ikeda K et al. (2005) Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol, 137 Suppl 1:45-50. (PubMed:15947484)
  6. Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun, 272:45-54. (PubMed:10872802)
  7. Ito T et al. (1994) Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A, 91:7455-9. (PubMed:7519779)
  8. Kieslinger M et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev, 14:232-44. (PubMed:10652277)
  9. Lum JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell, 120:237-48. (PubMed:15680329)
  10. Lum JJ et al. (2007) The transcription factor HIF-1{alpha} plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev, 21:1037-49. (PubMed:17437992)
  11. Miyazaki T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell, 81:223-31. (PubMed:7736574)
  12. Okada S et al. (1992) Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors. Exp Hematol, 20:546-51. (PubMed:1350248)
  13. Ploemacher RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia, 7:1374-80. (PubMed:7690439)
  14. Pope SM et al. (2005) Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. J Biol Chem, 280:13952-61. (PubMed:15647285)
  15. Seo SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem, 279:42240-9. (PubMed:15231831)
  16. Shelburne CP et al. (2003) Stat5 expression is critical for mast cell development and survival. Blood, 102:1290-7. (PubMed:12714518)
  17. Traver D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity, 9:47-57. (PubMed:9697835)
  18. Tsuji K et al. (1992) Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood, 79:2855-60. (PubMed:1375116)
  19. Xu J et al. (2002) The role of Asp-462 in regulating Akt activity. J Biol Chem, 277:35561-6. (PubMed:12124386)
  20. Yu C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell, 13:329-40. (PubMed:14967141)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory