Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il2rg. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il2rg
  • is located in the following cellular components:
    • external side of plasma membrane ^[5]
• Researchers have inferred, based on physical interactions, that the gene product of Il2rg
  • performs the following molecular functions:
    • interleukin-2 binding ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Il2rg
  • participates in the following biological processes:
    • positive regulation of B cell differentiation ^[3]
    • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ^[1]
    • positive regulation of gene expression ^[2]
    • positive regulation of T cell differentiation in thymus ^{[3, 4]}
    • regulation of gene expression ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il2rg:
  • performs the following molecular functions:
    • interleukin-2 binding
    • interleukin-7 binding
  • is located in the following cellular components:
    • cell surface

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Summary text based on GO annotations supported by structural data

• Il2rg encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Immunoglobulin-like fold, Interleukin-6 receptor alpha chain, binding, Short hematopoietin receptor, family 1, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • cytokine receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il2rg indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Fontenot JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol, 6:1142-51. (PubMed:16227984)
2. Jia J et al. (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol, 38:2806-20. (PubMed:18958875)
3. Kondo M et al. (1997) Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. Immunity, 7:155-62. (PubMed:9252128)
4. Nakajima H et al. (1999) Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. J Immunol, 162:782-90. (PubMed:9916699)
5. Zurawski SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J, 12:5113-9. (PubMed:8262055)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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