Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il1r1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il1r1
  • participates in the following biological processes:
    • cytokine-mediated signaling pathway ^{[4, 5]}
  • performs the following molecular functions:
    • interleukin-1 receptor activity ^[5]
    • signal transducer activity ^[5]
  • is located in the following cellular components:
    • cell surface ^[3]
• The gene product of Il1r1 has been shown to bind to the gene products of Irak1, Irak4. ^{[2, 4]} Researchers have inferred, based on physical interactions, that the gene product of Il1r1
  • performs the following molecular functions:
    • protease binding ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il1r1:
  • participates in the following biological processes:
    • interleukin-1-mediated signaling pathway
    • response to interleukin-1
  • performs the following molecular functions:
    • interleukin-1 receptor activity
    • ionotropic glutamate receptor binding
    • platelet-derived growth factor receptor binding
  • is located in the following cellular components:
    • extracellular space
    • membrane
    • nucleus
    • postsynaptic density
    • protein complex

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Summary text based on GO annotations supported by structural data

• Il1r1 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin I-set, Immunoglobulin subtype, Immunoglobulin-like domain, Immunoglobulin-like fold, Interleukin-1 receptor family, Interleukin-1 receptor IL1R, Interleukin-1 receptor, type I/II, Toll/interleukin-1 receptor homology (TIR) domain, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • interleukin-1, Type I, activating receptor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il1r1 indicates that it:
  • is located in the following cellular components:
    • extracellular region
    • integral to membrane
    • plasma membrane

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References

1. Amour A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett, 524:154-8. (PubMed:12135759)
2. Dripps DJ et al. (1991) Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J Biol Chem, 266:10331-6. (PubMed:1828071)
3. Inlay MA et al. (2009) Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev, 23:2376-81. (PubMed:19833765)
4. Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem, 279:40653-8. (PubMed:15292196)
5. Radons J et al. (2002) Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. J Biol Chem, 277:16456-63. (PubMed:11880380)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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