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Gene Ontology Classifications
Symbol
Name
ID
Casp1
caspase 1
MGI:96544

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Casp1. (This text reflects annotations as of Thursday, January 16, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Boyden ED et al. (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin Nat Genet, 38:240-244. (PubMed:16429160)
  2. Buck M et al. (2001) C/EBPbeta Phosphorylation by RSK Creates a Functional XEXD Caspase Inhibitory Box Critical for Cell Survival. Mol Cell, 8:807-16. (PubMed:11684016)
  3. Burckstummer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol, 10:266-72. (PubMed:19158679)
  4. Chen Y et al. (1996) A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J, 15:3853-60. (PubMed:8670890)
  5. Ha SD et al. (2012) Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol, 32:4846-60. (PubMed:23028046)
  6. Henao-Mejia J et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 482:179-85. (PubMed:22297845)
  7. Hersh D et al. (1999) The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A, 96:2396-401. (PubMed:10051653)
  8. Kayagaki N et al. (2011) Non-canonical inflammasome activation targets caspase-11. Nature, 479:117-21. (PubMed:22002608)
  9. Kofoed EM et al. (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature, 477:592-5. (PubMed:21874021)
  10. Mariathasan S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature, 430:213-8. (PubMed:15190255)
  11. Pelegrin P et al. (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol, 180:7147-57. (PubMed:18490713)
  12. Sarkar A et al. (2006) ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol, 176:4979-86. (PubMed:16585594)
  13. Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem, 276:125-32. (PubMed:11016935)
  14. Verhoef PA et al. (2005) Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol, 175:7623-34. (PubMed:16301672)
  15. Zhang WH et al. (2003) Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A, 100:16012-7. (PubMed:14663141)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory