Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cysteine-type endopeptidase activity. Involved in several processes, including AIM2 inflammasome complex assembly; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of interleukin-1 beta production. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is active in cytosol. Is expressed in forelimb mesenchyme; knee joint; metanephros; small intestine; and telencephalon. Orthologous to human CASP1 (caspase 1).