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Gene Ontology Classifications
Indian hedgehog

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ihh. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Akiyama H et al. (1999) Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs. Biochem Biophys Res Commun, 257:814-20. (PubMed:10208865)
  2. Astorga J et al. (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development, 134:3753-61. (PubMed:17881493)
  3. Capurro MI et al. (2009) Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. EMBO Rep, 10:901-7. (PubMed:19590577)
  4. Carpenter D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A, 95:13630-4. (PubMed:9811851)
  5. Chuang PT et al. (1999) Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature, 397:617-21. (PubMed:10050855)
  6. Colnot C et al. (2005) Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development, 132:1057-67. (PubMed:15689378)
  7. Dakubo GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol, 320:242-55. (PubMed:18582859)
  8. Gritli-Linde A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol, 236:364-86. (PubMed:11476578)
  9. Hebrok M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development, 127:4905-13. (PubMed:11044404)
  10. Hu H et al. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development, 132:49-60. (PubMed:15576404)
  11. Jacobs SB et al. (2007) Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Cell Death Differ, 14:1374-85. (PubMed:17464332)
  12. Kobayashi T et al. (2005) Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest, 115:1734-42. (PubMed:15951842)
  13. Koziel L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development, 132:5249-60. (PubMed:16284117)
  14. Long F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development, 128:5099-108. (PubMed:11748145)
  15. Long F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development, 131:1309-18. (PubMed:14973297)
  16. Outram SV et al. (2009) Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. Blood, 113:2217-28. (PubMed:19109233)
  17. Ramalho-Santos M et al. (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development, 127:2763-72. (PubMed:10821773)
  18. Razzaque MS et al. (2005) Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol, 207:453-61. (PubMed:16278811)
  19. Shibukawa Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn, 236:426-34. (PubMed:17191253)
  20. Witte F et al. (2010) Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Natl Acad Sci U S A, 107:14211-6. (PubMed:20660756)
  21. Yang Y et al. (1998) Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. Development, 125:3123-32. (PubMed:9671585)
  22. Young B et al. (2006) Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol, 299:272-82. (PubMed:16935278)
  23. Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell, 106:781-92. (PubMed:11517919)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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