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Gene Ontology Classifications
immunoglobulin heavy constant mu

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ighm. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text for additional MGI annotations
  1. Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol, 171:5562-70. (PubMed:14607964)
  2. Amsen D et al. (2007) Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity, 27:89-99. (PubMed:17658279)
  3. Bry L et al. (2004) Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol, 172:433-41. (PubMed:14688352)
  4. Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med, 183:1707-18. (PubMed:8666928)
  5. Castigli E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A, 101:3903-8. (PubMed:14988498)
  6. Chen Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR Nature, 407:916-20. (PubMed:11057672)
  7. Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature, 378:303-6. (PubMed:7477353)
  8. Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol, 13:1252-8. (PubMed:12867038)
  9. Erlandsson L et al. (2005) Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol, 35:1969-1976. (PubMed:15909309)
  10. Fujiwara H et al. (1994) The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A, 91:6835-9. (PubMed:8041705)
  11. Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol, 15:937-44. (PubMed:12882831)
  12. Helgason CD et al. (2000) A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med, 191:781-94. (PubMed:10704460)
  13. Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem, 270:27987-90. (PubMed:7499277)
  14. Klasener K et al. (2014) B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. Elife, 3:e02069. (PubMed:24963139)
  15. Kong YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol, 25:3431-6. (PubMed:8566034)
  16. Kretschmer K et al. (2003) The selection of marginal zone B cells differs from that of B-1a cells. J Immunol, 171:6495-501. (PubMed:14662849)
  17. Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med, 195:461-72. (PubMed:11854359)
  18. Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity, 8:233-43. (PubMed:9492004)
  19. Matsuuchi L et al. (1992) The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A, 89:3404-8. (PubMed:1373499)
  20. Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity, 10:249-59. (PubMed:10072077)
  21. Ng LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol, 173:807-17. (PubMed:15240667)
  22. Oettgen HC et al. (1994) Active anaphylaxis in IgE-deficient mice. Nature, 370:367-70. (PubMed:8047141)
  23. Pani G et al. (1997) The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med, 186:581-8. (PubMed:9254656)
  24. Rahman ZS et al. (2003) Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med, 198:1157-69. (PubMed:14557413)
  25. Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk prottein-tyrosine kinase. J Biol Chem, 271:6458-66. (PubMed:8626447)
  26. Roes J et al. (1993) Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med, 177:45-55. (PubMed:8418208)
  27. Scaglione BJ et al. (2007) Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br J Haematol, 139:645-57. (PubMed:17941951)
  28. Sexl V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5 Blood, 96:2277-83. (PubMed:10979977)
  29. Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science, 261:609-12. (PubMed:7688139)
  30. Takai T et al. (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature, 379:346-9. (PubMed:8552190)
  31. Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature, 378:298-302. (PubMed:7477352)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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