Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including embryonic placenta development; positive regulation of developmental growth; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within several processes, including exocrine pancreas development; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).