Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd79b. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd79b
  • participates in the following biological processes:
    • B cell receptor signaling pathway ^{[1, 2]}
  • is located in the following cellular components:
    • B cell receptor complex ^{[1, 2]}
    • external side of plasma membrane ^[1]
• The gene product of Cd79b has been shown to bind to the gene products of Cd79a. ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cd79b:
  • is located in the following cellular components:
    • cytoplasm
    • Golgi apparatus
    • nucleus
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Cd79b encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin subtype, Immunoglobulin V-set, Immunoglobulin-like, Immunoglobulin-like fold, Phosphorylated immunoreceptor signaling ITAM, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd79b indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Matsuuchi L et al. (1992) The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A, 89:3404-8. (PubMed:1373499)
2. Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk prottein-tyrosine kinase. J Biol Chem, 271:6458-66. (PubMed:8626447)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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