Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables endopeptidase activity. Involved in insulin catabolic process and insulin receptor recycling. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is active in endosome lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).