Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc6a4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc6a4
  • participates in the following biological processes:
    • cellular response to organic substance ^[1]
    • serotonin uptake ^[4]
• The gene product of Slc6a4 has been shown to bind to the gene products of Inadl. ^[4] Researchers have inferred, based on physical interactions, that the gene product of Slc6a4
  • performs the following molecular functions:
    • nitric-oxide synthase binding ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc6a4
  • participates in the following biological processes:
    • brain morphogenesis ^[5]
    • negative regulation of organ growth ^[5]
    • positive regulation of cell cycle ^[2]
    • positive regulation of gene expression ^[2]
    • serotonin transport ^[2]
    • serotonin uptake ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Slc6a4
  • participates in the following biological processes:
    • social behavior based on interactions with Pten ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc6a4:
  • participates in the following biological processes:
    • cellular response to cGMP
    • circadian rhythm
    • memory
    • monoamine transport
    • negative regulation of cerebellar granule cell precursor proliferation
    • negative regulation of neuron differentiation
    • negative regulation of synaptic transmission, dopaminergic
    • protein homooligomerization
    • protein oligomerization
    • response to toxin
    • serotonin transport
    • serotonin uptake
    • sperm ejaculation
    • thalamus development
    • vasoconstriction
  • performs the following molecular functions:
    • actin filament binding
    • cocaine binding
    • monoamine transmembrane transporter activity
    • myosin binding
    • protein homodimerization activity
    • Rab GTPase binding
    • serotonin transmembrane transporter activity
    • serotonin:sodium symporter activity
    • syntaxin-1 binding
  • is located in the following cellular components:
    • cytosol
    • endomembrane system
    • membrane raft
    • neuron projection
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc6a4 encodes a protein or proteins that contain the following InterPro domains: Sodium:neurotransmitter symporter, Sodium:neurotransmitter symporter, serotonin, N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • neurotransmitter transport
  • performs the following molecular functions:
    • neurotransmitter:sodium symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • integral to plasma membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc6a4 indicates that it:
  • participates in the following biological processes:
    • neurotransmitter transport
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • endosome
    • integral to membrane
    • membrane

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References

1. Arnold SJ et al. (2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev, 22:2479-84. (PubMed:18794345)
2. Asada M et al. (2009) Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia, 11:408-17. (PubMed:19308295)
3. Bengel D et al. (1998) Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. Mol Pharmacol, 53:649-55. (PubMed:9547354)
4. Chanrion B et al. (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A, 104:8119-24. (PubMed:17452640)
5. Page DT et al. (2009) Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A, 106:1989-94. (PubMed:19208814)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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