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Gene Ontology Classifications
Symbol
Name
ID
Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
MGI:96281

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Htr2c. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Heisler LK et al. (2007) Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci, 27:6956-64. (PubMed:17596444)
  3. Heisler LK et al. (2007) Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav, 6:491-6. (PubMed:17451451)
  4. Sohn JW et al. (2011) Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels. Neuron, 71:488-97. (PubMed:21835345)
  5. Tecott LH et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors [see comments] Nature, 374:542-6. (PubMed:7700379)
  6. Xu Y et al. (2010) A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci, 30:14630-4. (PubMed:21048120)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory