Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables protein folding chaperone; protein kinase binding activity; and tau protein binding activity. Contributes to protein kinase regulator activity. Involved in several processes, including cellular response to heat; negative regulation of proteasomal protein catabolic process; and protein folding. Acts upstream of or within cellular response to interleukin-4; negative regulation of apoptotic process; and placenta development. Located in growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of HSP90-CDC37 chaperone complex. Is expressed in several structures, including branchial arch; central nervous system; eye; jaw; and limb. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1).