Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hras1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hras1
  • participates in the following biological processes:
    • cell aging ^{[2, 9]}
    • endocytosis ^[7]
    • negative regulation of neuron apoptotic process ^[11]
    • positive regulation of cell proliferation ^[6]
    • positive regulation of gene expression ^[3]
    • small GTPase mediated signal transduction ^[12]
  • performs the following molecular functions:
    • GTP binding ^[5]
• The gene product of Hras1 has been shown to bind to the gene products of Rabgef1, Rassf5. ^{[1, 5, 8, 10]} Researchers have inferred, based on physical interactions, that the gene product of Hras1
  • participates in the following biological processes:
    • cell proliferation ^[12]
  • performs the following molecular functions:
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hras1
  • participates in the following biological processes:
    • intrinsic apoptotic signaling pathway ^[1]
    • regulation of long-term neuronal synaptic plasticity ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Hras1
  • participates in the following biological processes:
    • induction of apoptosis based on interactions with Bnip3 ^[1]
    • negative regulation of neuron apoptotic process based on interactions with Kras, Nf1 ^[11]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hras1:
  • participates in the following biological processes:
    • apoptotic process
    • cell cycle arrest
    • cellular senescence
    • mitotic cell cycle G1/S transition checkpoint
    • negative regulation of cell proliferation
    • negative regulation of gene expression
    • negative regulation of Rho GTPase activity
    • positive regulation of actin cytoskeleton reorganization
    • positive regulation of cell migration
    • positive regulation of cell proliferation
    • positive regulation of DNA replication
    • positive regulation of epithelial cell proliferation
    • positive regulation of ERK1 and ERK2 cascade
    • positive regulation of JNK cascade
    • positive regulation of MAP kinase activity
    • positive regulation of MAPK cascade
    • positive regulation of miRNA metabolic process
    • positive regulation of protein phosphorylation
    • positive regulation of Rac GTPase activity
    • positive regulation of Ras protein signal transduction
    • positive regulation of ruffle assembly
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of wound healing
    • protein heterooligomerization
    • Ras protein signal transduction
  • performs the following molecular functions:
    • GTP binding
    • protein C-terminus binding
  • is located in the following cellular components:
    • Golgi apparatus
    • intracellular membrane-bounded organelle
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Hras1 encodes a protein or proteins that contain the following InterPro domains: Small GTP-binding protein domain, Small GTPase superfamily, Small GTPase superfamily, Ras type, indicating that the gene product:
  • participates in the following biological processes:
    • GTP catabolic process
    • signal transduction
  • performs the following molecular functions:
    • GTPase activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hras1 indicates that it:
  • performs the following molecular functions:
    • nucleotide binding
  • is located in the following cellular components:
    • membrane

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References

1. An HJ et al. (2006) Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem, 281:33939-48. (PubMed:16954213)
2. Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A, 100:9354-9. (PubMed:12878730)
3. Gimferrer I et al. (2011) Regulation of GATA-3 Expression during CD4 Lineage Differentiation. J Immunol, 186:3892-8. (PubMed:21357543)
4. Komiyama NH et al. (2002) SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci, 22:9721-32. (PubMed:12427827)
5. Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol, 10:971-8. (PubMed:18604197)
6. Park KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci, 119:819-27. (PubMed:16478791)
7. Sun P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem, 278:4063-71. (PubMed:12446704)
8. Tam SY et al. (2004) RabGEF1 is a negative regulator of mast cell activation and skin inflammation. Nat Immunol, 5:844-52. (PubMed:15235600)
9. Tarunina M et al. (2004) Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol, 24:10792-801. (PubMed:15572682)
10. Vavvas D et al. (1998) Identification of Nore1 as a potential Ras effector. J Biol Chem, 273:5439-42. (PubMed:9488663)
11. Vogel KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci, 15:398-407. (PubMed:10845775)
12. Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene, 23:241-9. (PubMed:14712229)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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