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Gene Ontology Classifications
Symbol
Name
ID
Hras
Harvey rat sarcoma virus oncogene
MGI:96224

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hras. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. An HJ et al. (2006) Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem, 281:33939-48. (PubMed:16954213)
  2. Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A, 100:9354-9. (PubMed:12878730)
  3. Ghai R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A, 110:E643-52. (PubMed:23382219)
  4. Gimferrer I et al. (2011) Regulation of GATA-3 Expression during CD4 Lineage Differentiation. J Immunol, 186:3892-8. (PubMed:21357543)
  5. Komiyama NH et al. (2002) SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci, 22:9721-32. (PubMed:12427827)
  6. Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol, 10:971-8. (PubMed:18604197)
  7. Park KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci, 119:819-27. (PubMed:16478791)
  8. Shao H et al. (2000) A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. J Biol Chem, 275:26914-24. (PubMed:10869344)
  9. Stieglitz B et al. (2008) Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J, 27:1995-2005. (PubMed:18596699)
  10. Sun P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem, 278:4063-71. (PubMed:12446704)
  11. Tam SY et al. (2004) RabGEF1 is a negative regulator of mast cell activation and skin inflammation. Nat Immunol, 5:844-52. (PubMed:15235600)
  12. Tarunina M et al. (2004) Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol, 24:10792-801. (PubMed:15572682)
  13. Vavvas D et al. (1998) Identification of Nore1 as a potential Ras effector. J Biol Chem, 273:5439-42. (PubMed:9488663)
  14. Vogel KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci, 15:398-407. (PubMed:10845775)
  15. Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene, 23:241-9. (PubMed:14712229)
  16. Zalcman G et al. (1996) RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem, 271:30366-74. (PubMed:8939998)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory