Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables GTP binding activity and protein-membrane adaptor activity. Involved in several processes, including Ras protein signal transduction; insulin receptor signaling pathway; and nervous system development. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and oncogene-induced cell senescence. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of GTPase complex. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).