Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lipc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lipc
  • participates in the following biological processes:
    • metabolic process ^{[2, 3]}
  • performs the following molecular functions:
    • lipase activity ^{[2, 3]}
  • is located in the following cellular components:
    • extracellular space ^[2]
• The gene product of Lipc has been shown to bind to the gene products of Lmf1. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lipc
  • participates in the following biological processes:
    • cholesterol transport ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Lipc
  • participates in the following biological processes:
    • cholesterol homeostasis based on interactions with Apoa2 ^[5]
    • cholesterol metabolic process based on interactions with Apoa2 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lipc:
  • participates in the following biological processes:
    • cholesterol homeostasis
    • chylomicron remnant clearance
    • chylomicron remodeling
    • fatty acid biosynthetic process
    • fatty acid metabolic process
    • glycerophospholipid catabolic process
    • heparan sulfate proteoglycan biosynthetic process
    • high-density lipoprotein particle remodeling
    • low-density lipoprotein particle clearance
    • low-density lipoprotein particle remodeling
    • mRNA metabolic process
    • neutral lipid catabolic process
    • phosphatidic acid metabolic process
    • phosphatidylcholine metabolic process
    • phosphatidylethanolamine metabolic process
    • phosphatidylserine metabolic process
    • protein oligomerization
    • triglyceride catabolic process
    • triglyceride homeostasis
    • triglyceride metabolic process
    • very-low-density lipoprotein particle remodeling
  • performs the following molecular functions:
    • acylglycerol lipase activity
    • apolipoprotein binding
    • carboxylesterase activity
    • heparan sulfate proteoglycan binding
    • heparin binding
    • lipid binding
    • low-density lipoprotein particle binding
    • lysophospholipase activity
    • phosphatidylcholine 1-acylhydrolase activity
    • transferase activity, transferring acyl groups
    • triglyceride lipase activity
  • is located in the following cellular components:
    • cell surface
    • early endosome
    • extracellular space
    • late endosome
    • microvillus

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Summary text based on GO annotations supported by structural data

• Lipc encodes a protein or proteins that contain the following InterPro domains: Hepatic lipase, Lipase, Lipase, N-terminal, Lipase/lipooxygenase, PLAT/LH2, Lipoprotein lipase, LIPH, Lipoxygenase, LH2, indicating that the gene product:
  • participates in the following biological processes:
    • lipid metabolic process
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lipc indicates that it:
  • participates in the following biological processes:
    • lipid catabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • extracellular region
    • high-density lipoprotein particle
• Lipc has been associated with the Enzyme Commission numbers: 3.1.1.3, which implies that the gene product:
  • performs the following molecular functions:
    • retinyl-palmitate esterase activity

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References

1. Doolittle MH et al. (2009) Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biol Chem, 284:33623-33. (PubMed:19783858)
2. Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res, 46:2007-14. (PubMed:15995171)
3. Matsuki T et al. (2003) IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med, 198:877-88. (PubMed:12975454)
4. Wang N et al. (1996) Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor under fe J Biol Chem, 271:21001-4. (PubMed:8798380)
5. Weng W et al. (1999) ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice. J Lipid Res, 40:1064-70. (PubMed:10357838)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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