Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxd4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hoxd4
  • participates in the following biological processes:
    • stem cell differentiation ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hoxd4
  • participates in the following biological processes:
    • anterior/posterior pattern specification ^[1]
    • embryonic skeletal system morphogenesis ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Hoxd4
  • participates in the following biological processes:
    • anterior/posterior pattern specification based on interactions with Hoxa4 ^[2]
    • embryonic skeletal system morphogenesis based on interactions with Hoxa4 ^[2]

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Summary text based on GO annotations supported by structural data

• Hoxd4 encodes a protein or proteins that contain the following InterPro domains: Homeobox protein, antennapedia type, Homeobox protein, antennapedia type, conserved site, Homeobox, conserved site, Homeodomain, Homeodomain, metazoa, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hoxd4 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • nucleus

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References

1. Horan GS et al. (1995) Mutations in paralogous hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function. Dev Biol, 169:359-372. (PubMed:7750651)
2. Horan GS et al. (1995) Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev, 9:1667-77. (PubMed:7628700)
3. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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