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Gene Ontology Classifications
Symbol
Name
ID
Hoxd13
homeobox D13
MGI:96205

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxd13. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Albrecht AN et al. (2002) The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev, 112:53-67. (PubMed:11850178)
  2. Bruneau S et al. (2001) The mouse hoxd13(spdh) mutation, a polyalanine expansion similar to human type ii synpolydactyly (spd), disrupts the function but not the expression of other hoxd genes. Dev Biol, 237:345-53. (PubMed:11543619)
  3. Capellini TD et al. (2006) Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development, 133:2263-73. (PubMed:16672333)
  4. Davis AP et al. (1996) A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. Development, 122:1175-85. (PubMed:8620844)
  5. Dolle P et al. (1993) Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell, 75:431-41. (PubMed:8106170)
  6. Economides KD et al. (2003) Hoxb13 is required for normal differentiation and secretory function of the ventral prostate. Development, 130:2061-9. (PubMed:12668621)
  7. Herault Y et al. (1997) Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development, 124:3493-500. (PubMed:9342042)
  8. Herault Y et al. (1996) Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J, 15:6727-38. (PubMed:8978698)
  9. Kawakami Y et al. (2009) Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development, 136:585-94. (PubMed:19168674)
  10. Podlasek CA et al. (1997) Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Dev Dyn, 208:454-65. (PubMed:9097018)
  11. Salsi V et al. (2006) Hoxd13 and Hoxa13 directly control the expression of the EphA7 Ephrin tyrosine kinase receptor in developing limbs. J Biol Chem, 281:1992-9. (PubMed:16314414)
  12. Sheth R et al. (2007) Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev Biol, 310:430-41. (PubMed:17714700)
  13. Williams TM et al. (2005) Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev Biol, 277:457-71. (PubMed:15617687)
  14. Zakany J et al. (1996) Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature, 384:69-71. (PubMed:8900279)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory