Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxd10. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hoxd10
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^{[1, 7]}
  • performs the following molecular functions:
    • chromatin binding ^[1]
    • DNA binding ^[7]
    • sequence-specific DNA binding transcription factor activity ^[7]
• The gene product of Hoxd10 has been shown to bind to the gene products of Gmnn. ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hoxd10
  • participates in the following biological processes:
    • skeletal system development ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Hoxd10
  • participates in the following biological processes:
    • adult locomotory behavior based on interactions with Hoxd9 ^[3]
    • anterior/posterior pattern specification based on interactions with Hoxa10, Hoxc10, Hoxd9 ^{[3, 5]}
    • embryonic limb morphogenesis based on interactions with Hoxa10, Hoxc10 ^[5]
    • embryonic skeletal system morphogenesis based on interactions with Hoxd9 ^[3]
    • forelimb morphogenesis based on interactions with Hoxd9 ^[3]
    • hindlimb morphogenesis based on interactions with Hoxd9 ^[3]
    • neuromuscular process based on interactions with Hoxc10 ^[6]
    • peripheral nervous system neuron development based on interactions with Hoxd9 ^[3]
    • proximal/distal pattern formation based on interactions with Hoxa10, Hoxc10 ^[5]
    • skeletal muscle tissue development based on interactions with Hoxd9 ^[3]
    • skeletal system development based on interactions with Hoxa10, Hoxc10 ^[5]
    • spinal cord motor neuron cell fate specification based on interactions with Hoxc10 ^[6]

---

Summary text based on GO annotations supported by structural data

• Hoxd10 encodes a protein or proteins that contain the following InterPro domains: Homeobox, conserved site, Homeodomain, Homeodomain, metazoa, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding
  • is located in the following cellular components:
    • nucleus

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hoxd10 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • is located in the following cellular components:
    • nucleus

---

References

1. Capellini TD et al. (2006) Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development, 133:2263-73. (PubMed:16672333)
2. Carpenter EM et al. (1997) Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development, 124:4505-14. (PubMed:9409668)
3. de la Cruz CC et al. (1999) Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol, 216:595-610. (PubMed:10642795)
4. Luo L et al. (2004) The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature, 427:749-53. (PubMed:14973489)
5. Wellik DM et al. (2003) Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science, 301:363-7. (PubMed:12869760)
6. Wu Y et al. (2008) Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development, 135:171-82. (PubMed:18065432)
7. Zappavigna V et al. (1991) HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. EMBO J, 10:4177-87. (PubMed:1756725)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---