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Gene Ontology Classifications
Symbol
Name
ID
Hoxd10
homeobox D10
MGI:96202

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxd10. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Capellini TD et al. (2006) Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development, 133:2263-73. (PubMed:16672333)
  2. Carpenter EM et al. (1997) Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development, 124:4505-14. (PubMed:9409668)
  3. de la Cruz CC et al. (1999) Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol, 216:595-610. (PubMed:10642795)
  4. Luo L et al. (2004) The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature, 427:749-53. (PubMed:14973489)
  5. Raines AM et al. (2013) Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Development, 140:2942-52. (PubMed:23760953)
  6. Wellik DM et al. (2003) Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science, 301:363-7. (PubMed:12869760)
  7. Wu Y et al. (2008) Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development, 135:171-82. (PubMed:18065432)
  8. Zappavigna V et al. (1991) HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. EMBO J, 10:4177-87. (PubMed:1756725)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory