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Gene Ontology Classifications
Symbol
Name
ID
Hoxa9
homeobox A9
MGI:96180

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxa9. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of similar genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important for hematopoeisis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Chen F et al. (1999) Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci U S A, 96:541-6. (PubMed:9892669)
  2. Chen F et al. (1997) Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol, 181:186-96. (PubMed:9013929)
  3. Dintilhac A et al. (2004) A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis. Gene Expr Patterns, 4:215-22. (PubMed:15161102)
  4. Fromental-Ramain C et al. (1996) Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development, 122:461-72. (PubMed:8625797)
  5. Fujino T et al. (2001) Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. Exp Hematol, 29:856-63. (PubMed:11438208)
  6. Magnusson M et al. (2007) Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects. Exp Hematol, 35:1421-8. (PubMed:17761289)
  7. McIntyre DC et al. (2007) Hox patterning of the vertebrate rib cage. Development, 134:2981-9. (PubMed:17626057)
  8. Raines AM et al. (2013) Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Development, 140:2942-52. (PubMed:23760953)
  9. Shen WF et al. (1997) AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol, 17:6448-58. (PubMed:9343407)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory