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Gene Ontology Classifications
Symbol
Name
ID
Hoxa13
homeobox A13
MGI:96173

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxa13. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Kawakami Y et al. (2009) Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development, 136:585-94. (PubMed:19168674)
  2. Morgan EA et al. (2003) Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development, 130:3095-109. (PubMed:12783783)
  3. Podlasek CA et al. (1999) Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate development. J Urol, 161:1655-61. (PubMed:10210434)
  4. Salsi V et al. (2006) Hoxd13 and Hoxa13 directly control the expression of the EphA7 Ephrin tyrosine kinase receptor in developing limbs. J Biol Chem, 281:1992-9. (PubMed:16314414)
  5. Shaut CA et al. (2008) HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet, 4:e1000073. (PubMed:18483557)
  6. Williams TM et al. (2005) Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability. Dev Biol, 279:462-80. (PubMed:15733672)
  7. Williams TM et al. (2005) Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev Biol, 277:457-71. (PubMed:15617687)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory