Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxa11. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hoxa11
  • participates in the following biological processes:
    • mesodermal cell fate specification ^[3]
    • multicellular organismal development ^[11]
    • positive regulation of transcription, DNA-dependent ^[3]
  • is located in the following cellular components:
    • protein complex ^[3]
    • protein-DNA complex ^[3]
    • transcription factor complex ^[8]
• The gene product of Hoxa11 has been shown to bind to the gene products of Gmnn. ^[6]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hoxa11
  • participates in the following biological processes:
    • skeletal system development ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Hoxa11
  • participates in the following biological processes:
    • anterior/posterior pattern specification based on interactions with Hoxc11, Hoxd11 ^[9]
    • branching involved in ureteric bud morphogenesis based on interactions with Hoxd11 ^[7]
    • cartilage development involved in endochondral bone morphogenesis based on interactions with Hoxd11 ^[1]
    • developmental growth based on interactions with Hoxd11 ^[1]
    • dorsal/ventral pattern formation based on interactions with Hoxd11 ^[7]
    • embryonic digit morphogenesis based on interactions with Hoxc11, Hoxd11 ^[9]
    • embryonic forelimb morphogenesis based on interactions with Hoxd11 ^[4]
    • embryonic limb morphogenesis based on interactions with Hoxd11 ^[1]
    • embryonic skeletal joint morphogenesis based on interactions with Hoxc11, Hoxd11 ^[5]
    • metanephros development based on interactions with Hoxc11, Hoxd11 ^[10]
    • organ induction based on interactions with Hoxc11, Hoxd11 ^[10]
    • positive regulation of cell development based on interactions with Hoxd11 ^[1]
    • positive regulation of chondrocyte differentiation based on interactions with Hoxd11 ^[1]
    • proximal/distal pattern formation based on interactions with Hoxc11, Hoxd11 ^[9]
    • regulation of chondrocyte differentiation based on interactions with Hoxd11 ^[4]
    • skeletal system development based on interactions with Hoxc11, Hoxd11 ^[9]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hoxa11:
  • is located in the following cellular components:
    • cytoplasm
    • nucleolus

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Summary text based on GO annotations supported by structural data

• Hoxa11 encodes a protein or proteins that contain the following InterPro domains: Domain of unknown function DUF3528, homeobox protein, eukaryotic, Homeobox, conserved site, Homeodomain, Homeodomain, metazoa, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hoxa11 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • is located in the following cellular components:
    • nucleus

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References

1. Boulet AM et al. (2004) Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development, 131:299-309. (PubMed:14668414)
2. Davis AP et al. (1995) Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature, 375:791-5. (PubMed:7596412)
3. Gong KQ et al. (2007) A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol, 27:7661-8. (PubMed:17785448)
4. Gross S et al. (2012) Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One, 7:e43553. (PubMed:22916278)
5. Koyama E et al. (2010) Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development, 137:3795-800. (PubMed:20978074)
6. Luo L et al. (2004) The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature, 427:749-53. (PubMed:14973489)
7. Patterson LT et al. (2001) Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development, 128:2153-61. (PubMed:11493536)
8. Shen WF et al. (1997) AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol, 17:6448-58. (PubMed:9343407)
9. Wellik DM et al. (2003) Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science, 301:363-7. (PubMed:12869760)
10. Wellik DM et al. (2002) Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev, 16:1423-32. (PubMed:12050119)
11. Zhao Y et al. (2002) Functional comparison of the hoxa 4, hoxa 10, and hoxa 11 homeoboxes. Dev Biol, 244:21-36. (PubMed:11900456)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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