About   Help   FAQ
Gene Ontology Classifications
homeobox A11

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxa11. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Boulet AM et al. (2004) Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development, 131:299-309. (PubMed:14668414)
  2. Davis AP et al. (1995) Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature, 375:791-5. (PubMed:7596412)
  3. Gong KQ et al. (2007) A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol, 27:7661-8. (PubMed:17785448)
  4. Gross S et al. (2012) Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One, 7:e43553. (PubMed:22916278)
  5. Koyama E et al. (2010) Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development, 137:3795-800. (PubMed:20978074)
  6. Luo L et al. (2004) The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature, 427:749-53. (PubMed:14973489)
  7. Park JS et al. (2012) Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell, 23:637-51. (PubMed:22902740)
  8. Patterson LT et al. (2001) Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development, 128:2153-61. (PubMed:11493536)
  9. Raines AM et al. (2013) Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Development, 140:2942-52. (PubMed:23760953)
  10. Shen WF et al. (1997) AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol, 17:6448-58. (PubMed:9343407)
  11. Wellik DM et al. (2003) Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science, 301:363-7. (PubMed:12869760)
  12. Wellik DM et al. (2002) Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev, 16:1423-32. (PubMed:12050119)
  13. Zhao Y et al. (2002) Functional comparison of the hoxa 4, hoxa 10, and hoxa 11 homeoboxes. Dev Biol, 244:21-36. (PubMed:11900456)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory