Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxa1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hoxa1
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[7]
    • regulation of transcription from RNA polymerase II promoter ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hoxa1
  • participates in the following biological processes:
    • anterior/posterior pattern specification ^[5]
    • central nervous system neuron differentiation ^[2]
    • facial nucleus development ^[1]
    • hindbrain development ^[5]
    • inner ear morphogenesis ^[5]
    • nervous system development ^[5]
    • rhombomere 3 development ^[2]
    • rhombomere 4 development ^{[1, 2]}
    • rhombomere 5 development ^{[1, 2]}
• Researchers have inferred, based on genetic interactions, that the gene product of Hoxa1
  • participates in the following biological processes:
    • anatomical structure formation involved in morphogenesis based on interactions with Hoxb1 ^[6]
    • anatomical structure morphogenesis based on interactions with Hoxb1 ^[6]
    • anterior/posterior pattern specification based on interactions with Hoxb1 ^[6]
    • facial nerve structural organization based on interactions with Egr2 ^[2]
    • motor neuron axon guidance based on interactions with Egr2 ^[2]
    • rhombomere 3 development based on interactions with Egr2 ^[2]
    • rhombomere 4 development based on interactions with Hoxb1 ^[6]
    • rhombomere 5 development based on interactions with Hoxb1 ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hoxa1:
  • participates in the following biological processes:
    • abducens nerve formation
    • anatomical structure morphogenesis
    • artery development
    • artery morphogenesis
    • cochlea development
    • cochlea morphogenesis
    • cognition
    • embryonic neurocranium morphogenesis
    • inner ear development
    • neuromuscular process
    • optokinetic behavior
    • outer ear morphogenesis
    • regulation of behavior
    • semicircular canal formation
    • sensory perception of sound

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Summary text based on GO annotations supported by structural data

• Hoxa1 encodes a protein or proteins that contain the following InterPro domains: Homeobox, conserved site, Homeodomain, Homeodomain, metazoa, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hoxa1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • nucleus

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References

1. Dolle P et al. (1993) Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci U S A, 90:7666-70. (PubMed:8102800)
2. Helmbacher F et al. (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development, 125:4739-48. (PubMed:9806922)
3. Lambert B et al. (2012) Protein interactions of the transcription factor Hoxa1. BMC Dev Biol, 12:29. (PubMed:23088713)
4. Pruitt SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr Patterns, 4:671-85. (PubMed:15465489)
5. Remacle S et al. (2004) Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol Cell Biol, 24:8567-75. (PubMed:15367676)
6. Rossel M et al. (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development, 126:5027-40. (PubMed:10529420)
7. Wassef MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development, 135:3369-78. (PubMed:18787068)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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