Automated description from the Alliance of Genome Resources (Release 3.0)
Predicted to have several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and protein homodimerization activity. Involved in several processes, including cellular response to cisplatin; cellular response to metal ion; and regulation of macroautophagy. Localizes to nucleus. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human HMOX1 (heme oxygenase 1).