Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in several processes, including negative regulation of amyloid-beta clearance; negative regulation of protein metabolic process; and visual learning. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and peroxisomal membrane. Is expressed in several structures, including branchial arch; central nervous system; ganglia; limb; and vibrissa. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).