Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription factor binding activity; cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in several processes, including regulation of gene expression; regulation of stem cell proliferation; and response to lipopolysaccharide. Acts upstream of or within several processes, including male gonad development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and spermatid nucleus differentiation. Located in cytoplasm; extracellular space; and nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; brain; branchial arch; retina; and urinary system. Orthologous to human HMGB2 (high mobility group box 2).