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Gene Ontology Classifications
Symbol
Name
ID
Nrg1
neuregulin 1
MGI:96083

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nrg1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
References
  1. Balana ME et al. (1999) Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas Oncogene, 18:6370-9. (PubMed:10597237)
  2. Calaora V et al. (2001) Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J Neurosci, 21:4740-51. (PubMed:11425901)
  3. Cotter L et al. (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science, 328:1415-8. (PubMed:20448149)
  4. Erickson SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development, 124:4999-5011. (PubMed:9362461)
  5. Gerlai R et al. (2000) Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks Behav Brain Res, 109:219-27. (PubMed:10762692)
  6. Grego-Bessa J et al. (2007) Notch signaling is essential for ventricular chamber development. Dev Cell, 12:415-29. (PubMed:17336907)
  7. Hippenmeyer S et al. (2002) A role for neuregulin1 signaling in muscle spindle differentiation. Neuron, 36:1035-49. (PubMed:12495620)
  8. Jevsek M et al. (2006) CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc Natl Acad Sci U S A, 103:6374-9. (PubMed:16606832)
  9. Jo SA et al. (1995) Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature, 373:158-61. (PubMed:7816098)
  10. Kao SC et al. (2009) Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science, 323:651-4. (PubMed:19179536)
  11. Kramer R et al. (1996) Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A, 93:4833-8. (PubMed:8643489)
  12. Liu X et al. (1998) Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc Natl Acad Sci U S A, 95:13024-9. (PubMed:9789034)
  13. Meyer D et al. (1995) Multiple essential functions of neuregulin in development [see comments] [published erratum appears in Nature 1995 Dec 14;378(6558):753] Nature, 378:386-90. (PubMed:7477375)
  14. Michailov GV et al. (2004) Axonal neuregulin-1 regulates myelin sheath thickness. Science, 304:700-3. (PubMed:15044753)
  15. Moscoso LM et al. (1995) Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev Biol, 172:158-69. (PubMed:7589796)
  16. Nishino J et al. (2010) Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci, 30:15228-40. (PubMed:21068328)
  17. Ozkaynak E et al. (2010) Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling. J Neurosci, 30:3857-64. (PubMed:20220021)
  18. Rentschler S et al. (2002) Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A, 99:10464-9. (PubMed:12149465)
  19. Rio C et al. (1997) Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron, 19:39-50. (PubMed:9247262)
  20. Sandrock AW Jr et al. (1997) Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo. Science, 276:599-603. (PubMed:9110980)
  21. Schmid RS et al. (2003) Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A, 100:4251-6. (PubMed:12649319)
  22. Shirakabe K et al. (2001) Roles of Meltrin beta /ADAM19 in the processing of neuregulin. J Biol Chem, 276:9352-8. (PubMed:11116142)
  23. Tansey MG et al. (1996) ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway. J Cell Biol, 134:465-76. (PubMed:8707830)
  24. Taveggia C et al. (2005) Neuregulin-1 type III determines the ensheathment fate of axons. Neuron, 47:681-94. (PubMed:16129398)
  25. Vartanian T et al. (1999) Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proc Natl Acad Sci U S A, 96:731-5. (PubMed:9892702)
  26. Viehover A et al. (2001) Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions. Dev Neurosci, 23:377-86. (PubMed:11756753)
  27. Wolpowitz D et al. (2000) Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron, 25:79-91. (PubMed:10707974)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory