Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including ERBB4 signaling pathway; positive regulation of cardiac muscle cell differentiation; and postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of protein phosphorylation. Located in several cellular components, including axon; neuromuscular junction; and plasma membrane. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).
Analysis Tools
Text File
Excel File