Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nrg1. (This text reflects annotations as of Tuesday, July 8, 2014.)

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nrg1
  • participates in the following biological processes:
    • cardiac conduction system development ^[]
    • cell morphogenesis ^[]
    • glial cell fate commitment ^[]
    • MAPK cascade ^[]
    • negative regulation of protein catabolic process ^[]
    • positive regulation of protein kinase activity ^{[, ]}
    • positive regulation of protein kinase B signaling ^[]
    • positive regulation of Ras protein signal transduction ^[]
  • performs the following molecular functions:
    • ErbB-2 class receptor binding ^[]
  • is located in the following cellular components:
    • axon ^[]
    • cytoplasm ^[]
    • integral component of plasma membrane ^[]
    • neuromuscular junction ^[]
    • plasma membrane ^[]
    • synapse ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nrg1
  • participates in the following biological processes:
    • glial cell differentiation ^{[, ]}
    • heart development ^{[, , ]}
    • locomotory behavior ^[]
    • muscle organ development ^[]
    • nervous system development ^[]
    • neuron fate commitment ^[]
    • neurotransmitter receptor metabolic process ^[]
    • peripheral nervous system development ^{[, ]}
    • regulation of cell differentiation ^{[, ]}
    • synapse assembly ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Nrg1
  • participates in the following biological processes:
    • cell migration based on interactions with Erbb4 ^[]
  • performs the following molecular functions:
    • ErbB-2 class receptor binding based on interactions with Erbb4 ^[]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nrg1:
  • participates in the following biological processes:
    • cellular protein complex disassembly
    • negative regulation of transcription, DNA-templated
  • performs the following molecular functions:
    • transcription cofactor activity

---

References

1. . () , :. (PubMed:)
2. . () , :. (PubMed:)
3. . () , :. (PubMed:)
4. . () , :. (PubMed:)
5. . () , :. (PubMed:)
6. . () , :. (PubMed:)
7. . () , :. (PubMed:)
8. . () , :. (PubMed:)
9. . () , :. (PubMed:)
10. . () , :. (PubMed:)
11. . () , :. (PubMed:)
12. . () , :. (PubMed:)
13. . () , :. (PubMed:)
14. . () , :. (PubMed:)
15. . () , :. (PubMed:)
16. . () , :. (PubMed:)
17. . () , :. (PubMed:)
18. . () , :. (PubMed:)
19. . () , :. (PubMed:)
20. . () , :. (PubMed:)
21. . () , :. (PubMed:)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---