Automated description from the Alliance of Genome Resources (Release 4.0)
Predicted to have beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; inner ear development; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to MHC protein complex; external side of plasma membrane; and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G).