Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have several functions, including TAP complex binding activity; beta-2-microglobulin binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to several cellular components, including Golgi medial cisterna; MHC class I protein complex; and endoplasmic reticulum. Is expressed in embryo; placenta; and spleen. Human ortholog(s) of this gene implicated in asthma and hepatitis C. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G).