Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of H2-Eb1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of H2-Eb1
  • participates in the following biological processes:
    • antigen processing and presentation of exogenous peptide antigen via MHC class II ^{[1, 4]}
    • response to interferon-gamma ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of H2-Eb1:
  • participates in the following biological processes:
    • detection of bacterium
    • humoral immune response mediated by circulating immunoglobulin
    • immune response
    • immunoglobulin production involved in immunoglobulin mediated immune response
    • inflammatory response to antigenic stimulus
    • negative regulation of inflammatory response to antigenic stimulus
    • negative regulation of interferon-gamma production
    • negative regulation of T cell proliferation
    • positive regulation of insulin secretion involved in cellular response to glucose stimulus
    • protein tetramerization
    • regulation of interleukin-10 secretion
    • regulation of interleukin-4 production
    • T-helper 1 type immune response
  • performs the following molecular functions:
    • peptide antigen binding
  • is located in the following cellular components:
    • external side of plasma membrane
    • late endosome membrane
    • lysosomal membrane

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Summary text based on GO annotations supported by structural data

• H2-Eb1 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin C1-set, Immunoglobulin-like, Immunoglobulin-like fold, Immunoglobulin/major histocompatibility complex, conserved site, MHC class II, alpha/beta chain, N-terminal, MHC class II, beta chain, N-terminal, MHC classes I/II-like antigen recognition protein, indicating that the gene product:
  • participates in the following biological processes:
    • antigen processing and presentation
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe H2-Eb1 indicates that it:
  • participates in the following biological processes:
    • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Alfonso C et al. (2001) The Impact of H2-DM on Humoral Immune Responses. J Immunol, 167:6348-55. (PubMed:11714799)
2. Luder CG et al. (2001) Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha. Eur J Immunol, 31:1475-84. (PubMed:11465104)
3. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)
4. Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer, 83:1192-201. (PubMed:11027433)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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