Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits peptide antigen binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell differentiation; and response to interferon-gamma. Localizes to MHC class II protein complex; external side of plasma membrane; and lysosome. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bone inflammation disease (multiple); glucose metabolism disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1).