Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of H2-Aa. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of H2-Aa
  • participates in the following biological processes:
    • antigen processing and presentation ^[4]
    • antigen processing and presentation of exogenous peptide antigen via MHC class II ^{[1, 4, 6, 8, 9, 10, 11, 13]}
    • antigen processing and presentation of peptide antigen ^[10]
    • positive regulation of T cell differentiation ^[8]
    • response to interferon-gamma ^[7]
  • performs the following molecular functions:
    • peptide antigen binding ^{[4, 10]}
  • is located in the following cellular components:
    • external side of plasma membrane ^{[2, 4, 6, 8, 9, 11, 12]}
    • lysosome ^[5]
    • MHC class II protein complex ^{[2, 3, 6, 8, 9, 11, 12]}
    • plasma membrane ^[5]
• The gene product of H2-Aa has been shown to bind to the gene products of H2-Ab1. ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of H2-Aa:
  • participates in the following biological processes:
    • negative regulation of T cell proliferation
  • performs the following molecular functions:
    • protein heterodimerization activity

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Summary text based on GO annotations supported by structural data

• H2-Aa encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin C1-set, Immunoglobulin-like, Immunoglobulin-like fold, Immunoglobulin/major histocompatibility complex, conserved site, MHC class II, alpha chain, N-terminal, MHC class II, alpha/beta chain, N-terminal, MHC classes I/II-like antigen recognition protein, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe H2-Aa indicates that it:
  • participates in the following biological processes:
    • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Alfonso C et al. (2001) The Impact of H2-DM on Humoral Immune Responses. J Immunol, 167:6348-55. (PubMed:11714799)
2. Fung-Leung WP et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science, 271:1278-81. (PubMed:8638109)
3. Karlsson L et al. (1994) Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science, 266:1569-73. (PubMed:7985028)
4. Kovats S et al. (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med, 187:245-51. (PubMed:9432982)
5. Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med, 195:461-72. (PubMed:11854359)
6. Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity, 8:233-43. (PubMed:9492004)
7. Luder CG et al. (2001) Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha. Eur J Immunol, 31:1475-84. (PubMed:11465104)
8. Martin WD et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell, 84:543-50. (PubMed:8598041)
9. Miyazaki T et al. (1996) Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell, 84:531-41. (PubMed:8598040)
10. Perraudeau M et al. (2000) Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice Eur J Immunol, 30:2871-80. (PubMed:11069069)
11. Viville S et al. (1993) Mice lacking the MHC class II-associated invariant chain. Cell, 72:635-48. (PubMed:7679955)
12. Walter W et al. (2001) H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem, 276:11086-91. (PubMed:11148202)
13. Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer, 83:1192-201. (PubMed:11027433)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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