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Gene Ontology Classifications
Symbol
Name
ID
H2-Aa
histocompatibility 2, class II antigen A, alpha
MGI:95895

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of H2-Aa. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Alfonso C et al. (2001) The Impact of H2-DM on Humoral Immune Responses. J Immunol, 167:6348-55. (PubMed:11714799)
  2. Fung-Leung WP et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science, 271:1278-81. (PubMed:8638109)
  3. Karlsson L et al. (1994) Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science, 266:1569-73. (PubMed:7985028)
  4. Kovats S et al. (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med, 187:245-51. (PubMed:9432982)
  5. Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med, 195:461-72. (PubMed:11854359)
  6. Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity, 8:233-43. (PubMed:9492004)
  7. Luder CG et al. (2001) Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha. Eur J Immunol, 31:1475-84. (PubMed:11465104)
  8. Martin WD et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell, 84:543-50. (PubMed:8598041)
  9. Miyazaki T et al. (1996) Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell, 84:531-41. (PubMed:8598040)
  10. Perraudeau M et al. (2000) Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice Eur J Immunol, 30:2871-80. (PubMed:11069069)
  11. Viville S et al. (1993) Mice lacking the MHC class II-associated invariant chain. Cell, 72:635-48. (PubMed:7679955)
  12. Walter W et al. (2001) H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem, 276:11086-91. (PubMed:11148202)
  13. Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer, 83:1192-201. (PubMed:11027433)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory