Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gsn. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gsn
  • is located in the following cellular components:
    • lamellipodium ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gsn
  • participates in the following biological processes:
    • vesicle-mediated transport ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gsn:
  • participates in the following biological processes:
    • actin filament polymerization
    • actin filament severing
    • actin polymerization or depolymerization
    • apoptotic process
    • cellular response to cadmium ion
    • cilium morphogenesis
    • phosphatidylinositol-mediated signaling
    • regulation of cell adhesion
  • performs the following molecular functions:
    • actin binding
  • is located in the following cellular components:
    • actin cytoskeleton
    • cytosol
    • extracellular region
    • extracellular space
    • extracellular vesicular exosome
    • perinuclear region of cytoplasm
    • protein complex
    • ruffle

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gsn indicates that it:
  • participates in the following biological processes:
    • actin filament capping
    • cell projection organization
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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References

1. Mejillano MR et al. (2004) Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell, 118:363-73. (PubMed:15294161)
2. Witke W et al. (2001) Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. J Cell Biol, 154:775-84. (PubMed:11514591)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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