Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have chaperone binding activity. Involved in several processes, including glial cell activation; positive regulation of cellular component organization; and regulation of defense response. Localizes to several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in several structures, including early conceptus; gonad; integument; nervous system; and placenta. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Orthologous to human GRN (granulin precursor).