Automated description from the Alliance of Genome Resources
Exhibits NMDA glutamate receptor activity; calcium channel activity; and neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Localizes to several cellular components, including the NMDA selective glutamate receptor complex; synaptic membrane; and synaptic vesicle. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; early infantile epileptic encephalopathy 27; and neurodegenerative disease (multiple). Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B).