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Gene Ontology Classifications
Symbol
Name
ID
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
MGI:95820

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grin2a. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 9, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
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  9. Gordey M et al. (2001) Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. Neuroscience, 105:987-97. (PubMed:11530236)
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  11. Inoue M et al. (2000) Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit. Br J Pharmacol, 129:239-41. (PubMed:10694228)
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  13. Kadotani H et al. (1998) Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C. Neuroreport, 9:471-5. (PubMed:9512392)
  14. Kadotani H et al. (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci, 16:7859-67. (PubMed:8987814)
  15. Kishimoto Y et al. (1997) Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A. Neuroreport, 8:3717-21. (PubMed:9427357)
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  17. Kiyama Y et al. (1998) Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit. J Neurosci, 18:6704-12. (PubMed:9712642)
  18. Kohr G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci, 23:10791-9. (PubMed:14645471)
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  26. Miyamoto Y et al. (2001) Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. J Neurosci, 21:750-7. (PubMed:11160454)
  27. Miyazaki T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett, 580:4057-64. (PubMed:16814779)
  28. Morikawa E et al. (1998) Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J Neurosci, 18:9727-32. (PubMed:9822733)
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  33. Rossi P et al. (2002) NMDA receptor 2 (NR2) C-terminal control of NR open probability regulates synaptic transmission and plasticity at a cerebellar synapse. J Neurosci, 22:9687-97. (PubMed:12427824)
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  35. Samuels BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron, 56:823-37. (PubMed:18054859)
  36. Sato Y et al. (2005) Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology, 102:557-61. (PubMed:15731593)
  37. Shmelkov SV et al. (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med, 16:598-602, 1p following 602. (PubMed:20418887)
  38. Snell LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res Mol Brain Res, 40:71-8. (PubMed:8840015)
  39. Son GH et al. (2006) Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity. J Neurosci, 26:3309-18. (PubMed:16554481)
  40. Spooren W et al. (2004) Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition. Psychopharmacology (Berl), 175:99-105. (PubMed:14985927)
  41. Sprengel R et al. (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell, 92:279-89. (PubMed:9458051)
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  44. Taniura H et al. (2007) Tex261 modulates the excitotoxic cell death induced by N-methyl-d-aspartate (NMDA) receptor activation. Biochem Biophys Res Commun, 362:1096-100. (PubMed:17803966)
  45. Tao YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci, 23:6703-12. (PubMed:12890763)
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  47. Ventruti A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience, 189:32-42. (PubMed:21664258)
  48. Wang X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet, 20:3093-108. (PubMed:21558424)
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Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory