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Gene Ontology Classifications
glutamate receptor, ionotropic, NMDA2A (epsilon 1)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grin2a. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 9, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Abe M et al. (2004) NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J Neurosci, 24:7292-304. (PubMed:15317856)
  2. Amparan D et al. (2005) Direct interaction of myosin regulatory light chain with the NMDA receptor. J Neurochem, 92:349-61. (PubMed:15663482)
  3. Bajaj G et al. (2009) N-methyl-D-aspartate receptor subunits are non-myosin targets of myosin regulatory light chain. J Biol Chem, 284:1252-66. (PubMed:18945678)
  4. Bamji SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron, 40:719-31. (PubMed:14622577)
  5. Chazot PL et al. (1997) Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J Neurochem, 68:507-16. (PubMed:9003035)
  6. Chazot PL et al. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J Biol Chem, 269:24403-9. (PubMed:7929101)
  7. Chen JJ et al. (2001) Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci, 21:6348-61. (PubMed:11487658)
  8. Fernandez E et al. (2009) Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol, 5:269. (PubMed:19455133)
  9. Gordey M et al. (2001) Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. Neuroscience, 105:987-97. (PubMed:11530236)
  10. Hoe HS et al. (2006) Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem, 281:3425-31. (PubMed:16332682)
  11. Inoue M et al. (2000) Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit. Br J Pharmacol, 129:239-41. (PubMed:10694228)
  12. Ito I et al. (1997) Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit. J Physiol, 500:401-8. (PubMed:9147327)
  13. Jin SX et al. (2010) Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling. PLoS One, 5:e11732. (PubMed:20661302)
  14. Kadotani H et al. (1998) Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C. Neuroreport, 9:471-5. (PubMed:9512392)
  15. Kadotani H et al. (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci, 16:7859-67. (PubMed:8987814)
  16. Kishimoto Y et al. (1997) Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A. Neuroreport, 8:3717-21. (PubMed:9427357)
  17. Kitamura T et al. (2003) Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit. Neurosci Res, 47:55-63. (PubMed:12941447)
  18. Kiyama Y et al. (1998) Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit. J Neurosci, 18:6704-12. (PubMed:9712642)
  19. Kohr G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci, 23:10791-9. (PubMed:14645471)
  20. Kurschner C et al. (1998) CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci, 11:161-72. (PubMed:9647694)
  21. Kutsuwada T et al. (1992) Molecular diversity of the NMDA receptor channel [see comments] Nature, 358:36-41. (PubMed:1377365)
  22. Meguro H et al. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature, 357:70-4. (PubMed:1374164)
  23. Metzler M et al. (2007) NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1. J Neurosci, 27:2298-308. (PubMed:17329427)
  24. Minami T et al. (2000) Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice. Neuroscience, 97:133-42. (PubMed:10771345)
  25. Miyamoto H et al. (2003) Experience-dependent slow-wave sleep development. Nat Neurosci, 6:553-4. (PubMed:12754515)
  26. Miyamoto Y et al. (2004) Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit. Eur J Neurosci, 19:151-8. (PubMed:14750973)
  27. Miyamoto Y et al. (2001) Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. J Neurosci, 21:750-7. (PubMed:11160454)
  28. Miyazaki T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett, 580:4057-64. (PubMed:16814779)
  29. Morikawa E et al. (1998) Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J Neurosci, 18:9727-32. (PubMed:9822733)
  30. Munton RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics, 6:283-93. (PubMed:17114649)
  31. Nakazawa T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J, 25:2867-77. (PubMed:16710293)
  32. Ng D et al. (2009) Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol, 7:e41. (PubMed:19243221)
  33. Oshima S et al. (2002) Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. Neurosci Res, 43:239-50. (PubMed:12103442)
  34. Qiu S et al. (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol, 97:2312-21. (PubMed:17229826)
  35. Rossi P et al. (2002) NMDA receptor 2 (NR2) C-terminal control of NR open probability regulates synaptic transmission and plasticity at a cerebellar synapse. J Neurosci, 22:9687-97. (PubMed:12427824)
  36. Sakimura K et al. (1995) Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature, 373:151-5. (PubMed:7816096)
  37. Samuels BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron, 56:823-37. (PubMed:18054859)
  38. Sato Y et al. (2005) Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology, 102:557-61. (PubMed:15731593)
  39. Shmelkov SV et al. (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med, 16:598-602, 1p following 602. (PubMed:20418887)
  40. Snell LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res Mol Brain Res, 40:71-8. (PubMed:8840015)
  41. Son GH et al. (2006) Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity. J Neurosci, 26:3309-18. (PubMed:16554481)
  42. Spooren W et al. (2004) Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition. Psychopharmacology (Berl), 175:99-105. (PubMed:14985927)
  43. Sprengel R et al. (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell, 92:279-89. (PubMed:9458051)
  44. Takahashi T et al. (1996) Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum. J Neurosci, 16:4376-82. (PubMed:8699248)
  45. Takeuchi T et al. (2001) Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur J Neurosci, 14:153-60. (PubMed:11488959)
  46. Taniura H et al. (2007) Tex261 modulates the excitotoxic cell death induced by N-methyl-d-aspartate (NMDA) receptor activation. Biochem Biophys Res Commun, 362:1096-100. (PubMed:17803966)
  47. Tao YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci, 23:6703-12. (PubMed:12890763)
  48. Toyoda H et al. (2005) Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur J Neurosci, 22:485-94. (PubMed:16045501)
  49. Ventruti A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience, 189:32-42. (PubMed:21664258)
  50. Wang X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet, 20:3093-108. (PubMed:21558424)
  51. Zhao MG et al. (2005) Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47:859-72. (PubMed:16157280)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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